Related Experiment Video
Updated: Aug 7, 2026

Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice
Published on: February 18, 2016
Effects of chlordiazepoxide and d-amphetamine on responding suppressed by conditioned punishment
Abstract:
Key pecking by two pigeons, maintained under a variable-interval two-minute schedule of food presentation, was suppressed when each response produced a five-second visual stimulus that was occasionally paired with shock. Stimulus-shock pairings occurred independently of responding according to a variable-time six-minute schedule for one bird or once per session for the other bird. The effects of chlordiazepoxide and d-amphetamine were assessed on this baseline of behavior suppressed by conditioned punishment. Chlordiazepoxide produced dose-related increases in the rate of punished responding, whereas d-amphetamine produced only decreases. In addition, chlordiazepoxide produced dose-related increases in response rate during the response-produced and response-independent stimulus presentations; d-amphetamine, however, only decreased responding during stimulus presentations.
Related Concept Videos
Classical Conditioning in Daily Life
John B. Watson and Rosalie Rayner famously demonstrated the development of fear through classical conditioning in their experiment with Little Albert. They paired the...
Desensitization and Tachyphylaxis
Several...
Adrenergic Agonists: Indirect-Acting Agents
One mechanism involves depleting stored catecholamines by displacing them from synaptic vesicles. These agents, known as "displacers," are transported into vesicles at the expense of noradrenaline. Examples include amphetamine and tyramine, which lack a catechol moiety, resulting in prolonged action, improved oral bioavailability, and...
Principles of Classical Conditioning
During the...
CNS Stimulants: Cocaine, Amphetamines and Cannabinoids
Real-World Application of Classical Conditioning
Higher-order, or second-order, conditioning occurs when a neutral stimulus becomes associated with an already established conditioned stimulus through repeated pairings. For instance, if a dog has been...

