Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Microbubble expansion in a flexible tube.

Tao Ye1, Joseph L Bull

  • 1Biomedical Engineering Department, The University of Michigan, Ann Arbor, MI 48109, USA.

Journal of Biomechanical Engineering
|July 4, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lysosomal destabilization: A missing link between pathological calcification and osteoarthritis.

Bioactive materials·2024
Same author

Identification and Validation of the Glycolysis and Immune-related Gene Signature for Prognosis in Colorectal Cancer.

Anticancer research·2023
Same author

Decreased expression of ATP-binding cassette protein G1 promotes abnormal adipogenesis of condylar chondrocytes in temporomandibular joint osteoarthritis.

Journal of oral rehabilitation·2023
Same author

KCNN4 links PIEZO-dependent mechanotransduction to NLRP3 inflammasome activation.

Science immunology·2023
Same author

The association between fibrinogen levels and severity of coronary artery disease and long-term prognosis following percutaneous coronary intervention in patients with type 2 diabetes mellitus.

Frontiers in endocrinology·2023
Same author

Recent Advancements of Bioinks for 3D Bioprinting of Human Tissues and Organs.

ACS applied bio materials·2023

Acoustic vaporization of perfluorocarbon droplets in flexible blood vessels shows reduced vessel wall stress. This computational study suggests larger, more flexible vessels are less prone to damage during gas embolotherapy.

Area of Science:

  • Biomedical Engineering
  • Fluid Dynamics
  • Acoustic Cavitation

Background:

  • Gas embolotherapy using perfluorocarbon droplets is a novel tumor treatment.
  • Acoustic vaporization of these droplets can potentially damage blood vessels.

Purpose of the Study:

  • To investigate the effects of initial bubble size on blood vessel wall stress during acoustic droplet vaporization.
  • To model the acoustic vaporization of perfluorocarbon droplets in a flexible tube simulating an arteriole.

Main Methods:

  • Utilized a computational model employing a fixed grid, multi-domain, interface tracking, direct numerical simulation.
  • Simulated microbubble expansion in a liquid-filled flexible tube, modeling key dimensionless parameters.

Main Results:

Related Experiment Videos

  • Flexible tubes significantly dissipate pressure compared to rigid tubes, reducing peak pressure and expansion time.
  • Two primary flow regimes observed: inflow at tube ends and outflow near the bubble surface.
  • Smaller initial bubble diameters relative to vessel diameter resulted in lower wall stresses.

Conclusions:

  • Vessel wall flexibility plays a crucial role in mitigating wall stresses from acoustic droplet vaporization.
  • Acoustic activation in larger, more flexible vessels may pose a lower risk of vessel damage or rupture compared to smaller, stiffer vessels.