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Updated: Aug 7, 2026

Determination of Reproductive Competence by Confirming Pubertal Onset and Performing a Fertility Assay in Mice and Rats
Published on: October 13, 2018
Prepubertal menarche: a defined clinical entity
Shanthi M Pinto1, Anne S Garden
1Warrington Hospital, Merseyside, United Kingdom.
Abstract:
Prepubertal vaginal bleeding is considered as isolated menarche when, in the absence of detectable abnormality, it is not accompanied by any evidence of sexual development. The etiology remains unclear and various hypotheses have been put forward. This is the first time that a series of ultrasound patients with prepubertal menarche whose investigation has included imaging with ultrasound has been described. This paper illustrates isolated prepubertal menarche without the presence of an endometrial echo.
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