Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Renal function in patients with nephrolithiasis.

Elaine M Worcester1, Joan H Parks, Andrew P Evan

  • 1Nephrology Section, University of Chicago, Illinois, USA. eworcest@medicine.bsd.uchicago.edu

The Journal of Urology
|July 4, 2006
PubMed
Summary

Kidney function is impaired in most patients with kidney stones, regardless of stone type. This highlights the importance of managing kidney stones to prevent further renal injury.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Patient Perceptions of Dietary Supplement Use and Kidney Stone Disease.

Nutrients·2026
Same author

Validation of a Renal Papillary Grading System: Comparison of Patients Forming Calcium Oxalate and Apatite Stones.

Journal of endourology·2026
Same author

Kidney-specific claudin-2 deficiency leads to medullary nephrocalcinosis in mice.

The Journal of clinical investigation·2025
Same author

Urine organic anion increases with age and its effects on renal acid excretion vary with pKa.

American journal of physiology. Regulatory, integrative and comparative physiology·2025
Same author

Two distinct phenotypes of calcium oxalate stone formers could imply different long-term risks for renal function.

Urolithiasis·2024
Same author

Two distinct phenotypes of calcium oxalate stone formers could imply different long-term risks for renal function.

Research square·2024

Area of Science:

  • Nephrology
  • Urology
  • Biochemistry

Background:

  • Kidney stones (nephrolithiasis) are a significant health concern.
  • Understanding kidney function in stone formers is crucial for effective management.
  • Systemic etiologies and stone composition can influence kidney health.

Purpose of the Study:

  • To assess kidney function, specifically creatinine clearance, in individuals forming kidney stones.
  • To correlate kidney function with the type of kidney stone formed.
  • To investigate the impact of systemic etiologies on kidney function in stone formers.

Main Methods:

  • Measured 24-hour creatinine clearance in 1,856 kidney stone formers and 153 controls.
  • Adjusted creatinine clearance values for patient sex, age, and body weight using general linear modeling.

Related Experiment Videos

  • Classified stone formers based on stone type and systemic etiologies.

    • Main Results:

    • All groups of kidney stone formers exhibited decreased creatinine clearance compared to normal individuals.
    • Creatinine clearance was notably low in cystine and struvite stone formers.
    • Even common calcium oxalate (CaOx) stone formers showed below-normal kidney function.

    Conclusions:

    • Patients with kidney stones generally do not possess normal kidney function.
    • Clinical management should prioritize minimizing renal injury.
    • Balancing the risks of stone obstruction against urological procedures is essential.