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In vitro anti-proliferative and antioxidant studies on Devil's Club Oplopanax horridus
Joseph Tai1, Susan Cheung, Stefanie Cheah
1Department of Pathology and Pediatrics, Center for Complementary Medicine Research, BC Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada. jtai@interchange.ubc.ca
Abstract:
Devil's Club, Oplopanax horridus (OH), is a widely used folk medicine in Alaska and British Columbia for treating a variety of ailments including arthritis, fever and diabetes. HPLC profiling shows that numerous compounds are present in the 70% ethanolic extract of OH dry root bark powder. OH extract inhibited K562, HL60, MCF7 and MDA-MB-468 cell growth with the 50% inhibition (IC(50)) estimated at 1/2700, 1/1700, 1/500 and 1/2500 dilutions, respectively. Non-cytotoxic concentrations (
