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Related Experiment Videos

Post-mortem tissue sampling using computed tomography guidance.

Emin Aghayev1, Michael J Thali, Martin Sonnenschein

  • 1Institute of Forensic Medicine, University of Bern, IRM Buehlstrasse 20, CH-3012 Bern, Switzerland. emin.aghayev@irm.unibe.ch

Forensic Science International
|July 4, 2006
PubMed
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Post-mortem minimally invasive tissue sampling using computed tomography (CT) guidance with a biopsy needle provides adequate tissue samples for histological analysis. This technique enhances the potential of virtual autopsy by enabling targeted tissue probe collection.

Area of Science:

  • Forensic Medicine
  • Radiology
  • Pathology

Background:

  • Cross-sectional imaging like computed tomography (CT) is increasingly used in forensic medicine.
  • Current imaging methods lack cellular-level tissue detail and specific analyses (e.g., DNA, toxicology).
  • Virtual autopsy limitations necessitate improved tissue sampling methods.

Purpose of the Study:

  • To evaluate the efficacy of CT-guided minimally invasive needle biopsies for post-mortem tissue sampling.
  • To determine if clinically approved biopsy needles are suitable for post-mortem tissue acquisition.

Main Methods:

  • ACN III biopsy core needles (14 gauge x 160 mm) were utilized with an automatic pistol device.
  • Minimally invasive tissue probes were obtained from brain, heart, lung, liver, spleen, kidney, and muscle tissue under CT fluoroscopy guidance.

Related Experiment Videos

  • Three research-dedicated bodies were used for the study.

    • Main Results:

    • CT fluoroscopy ensured accurate needle placement within various organs and tissues.
    • The needles successfully sampled tissue probes with a mean width of 1.7 mm and maximal length of 20 mm.
    • Obtained tissue specimens were of sufficient size and quality for subsequent histological examination.

    Conclusions:

    • Clinically approved biopsy needles yield post-mortem tissue specimens suitable for histological analysis, mirroring clinical findings across multiple organs.
    • CT-guided post-mortem biopsy offers a reliable method for targeted tissue sampling.
    • This technique holds promise for enhancing virtual autopsy capabilities.