Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Stem cell enrichment approaches.

Paul C Park1, Shamini Selvarajah, Jane Bayani

  • 1Department of Pathology and Laboratory Medicine, The Ottawa Hospital, 501 Smyth Road, Ottawa, Ont., Canada K1H 8L6.

Seminars in Cancer Biology
|July 4, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Targeting B7-H3 in patients with metastatic triple-negative breast cancer and brain metastases: an opportunity to "revive" immunotherapy as a treatment strategy?

Journal for immunotherapy of cancer·2026
Same author

Population-Level Resources and Costs Associated with Low-Risk Prostate Cancer Patients on Active Surveillance.

Cancers·2026
Same author

Impact of Genomic Mutations on the Transcriptional Pathways and Tumor Microenvironment Landscape of Localized Early Prostate Cancer.

The Prostate·2026
Same author

Transfer Learning and Machine Learning for Training Five-Year Survival Prognostic Models in Early Breast Cancer: Development and Validation Study.

Journal of medical Internet research·2026
Same author

Heterogeneity and immune microenvironment of early invasive estrogen receptor-positive breast cancer reveal an immune-rich subset.

NPJ breast cancer·2026
Same author

Prognostic and predictive performance of PREDICT 2.1, PREDICT v3, and RSClin in node-negative early breast cancer: a TEAM pathology substudy.

Breast cancer research and treatment·2026
Same journal

Role of oral microbiome in cancer immunotherapy.

Seminars in cancer biology·2026
Same journal

Unveiling tumor heterogeneity by single cell RNA-sequencing: From basic considerations to clinical applications.

Seminars in cancer biology·2026
Same journal

Hidden architecture of resistance: The extracellular matrix in melanoma's immune landscape.

Seminars in cancer biology·2026
Same journal

Microfluidic technologies for extracellular vesicle isolation and analysis: Implications for translational applications in cancer therapy.

Seminars in cancer biology·2026
Same journal

Exploring glioblastoma microenvironment using organoids: opportunities, limitations, and emerging concepts.

Seminars in cancer biology·2026
Same journal

Special issue: Lipid metabolic alterations in cancer: Pathogenic mechanisms, therapies and common pathophysiology with cardiovascular disease.

Seminars in cancer biology·2026
See all related articles

Adult stem cells maintain tissues and tumors. Isolation strategies are reviewed, highlighting limitations due to heterogeneous cell populations and the concept of stemness as a spectrum rather than a distinct state.

Area of Science:

  • Stem cell biology
  • Cancer research
  • Tissue regeneration

Background:

  • Adult somatic tissues and their associated tumors are sustained by stem cells.
  • Stem cells possess self-renewal and pluripotency, along with specific phenotypic traits.
  • These traits are utilized for stem cell isolation and enrichment strategies.

Purpose of the Study:

  • To review stem cell isolation strategies and their inherent limitations.
  • To focus on mesenchymal tissue and bone tumor stem cell isolation.
  • To discuss the concept of stemness as a continuous spectrum.

Main Methods:

  • Review of existing literature on stem cell isolation techniques.
  • Analysis of phenotypic traits used for stem cell identification.

Related Experiment Videos

  • Emphasis on mesenchymal stem cells and bone tumor stem cells.

    • Main Results:

    • Stem cell isolation methods often yield heterogeneous and variable cell populations.
    • Phenotypic traits used for isolation are not exclusive to stem cells.
    • The concept of stemness is evolving, suggesting it's a state along a spectrum.

    Conclusions:

    • Current stem cell isolation strategies face significant limitations.
    • Stemness is influenced by phenotypic markers, epigenetic factors, and the microenvironment.
    • Stem cells may represent a dynamic state rather than a fixed entity.