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Related Concept Videos

Yeast Signaling01:28

Yeast Signaling

Yeasts are single-celled organisms, but unlike bacteria, they are eukaryotes (cells with a nucleus). Cell signaling in yeast is similar to signaling in other eukaryotic cells. A ligand, such as a protein or a small molecule released from a yeast cell, attaches to a receptor on the cell surface. The binding stimulates second-messenger kinases to activate or inactivate transcription factors that further regulate gene expression. Many of the yeast intracellular signaling cascades have similar...
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Related Experiment Video

Updated: Jun 27, 2026

Targeted in Situ Mutagenesis of Histone Genes in Budding Yeast
08:48

Targeted in Situ Mutagenesis of Histone Genes in Budding Yeast

Published on: January 26, 2017

Gene amplification: yeast takes a turn.

James E Haber1, Michelle Debatisse

  • 1Rosenstiel Center and Department of Biology, Brandeis University, Waltham, MA 02254, USA. haber@brandeis.edu

Cell
|July 4, 2006
PubMed
Summary

Palindromic sequences play a key role in gene amplification in budding yeast. Understanding this mechanism helps analyze gene amplification origins, overcoming challenges posed by genome rearrangements in mammalian cells.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cell Biology

Background:

  • Gene amplification in mammalian cells is challenging to study due to secondary genome rearrangements.
  • Recent research in budding yeast offers new perspectives on gene amplification mechanisms.

Purpose of the Study:

  • To investigate the role of palindromic sequences in gene amplification.
  • To provide insights into the origins of gene amplification.

Main Methods:

  • Utilized budding yeast as a model organism.
  • Analyzed the influence of palindromic sequences on gene amplification.

Main Results:

  • Identified palindromic sequences as significant factors in gene amplification.
  • Demonstrated a link between palindromic sequences and the initiation of gene amplification.

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Mitochondrial Transformation in Baker's Yeast to Study Translation and Respiratory Complex Assembly
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Mitochondrial Transformation in Baker's Yeast to Study Translation and Respiratory Complex Assembly

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Last Updated: Jun 27, 2026

Targeted in Situ Mutagenesis of Histone Genes in Budding Yeast
08:48

Targeted in Situ Mutagenesis of Histone Genes in Budding Yeast

Published on: January 26, 2017

Gene-targeted Random Mutagenesis to Select Heterochromatin-destabilizing Proteasome Mutants in Fission Yeast
07:18

Gene-targeted Random Mutagenesis to Select Heterochromatin-destabilizing Proteasome Mutants in Fission Yeast

Published on: May 15, 2018

Mitochondrial Transformation in Baker's Yeast to Study Translation and Respiratory Complex Assembly
09:53

Mitochondrial Transformation in Baker's Yeast to Study Translation and Respiratory Complex Assembly

Published on: June 7, 2024

Conclusions:

  • Palindromic sequences are crucial for understanding gene amplification processes.
  • This research advances the analysis of gene amplification origins in eukaryotic cells.