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Related Experiment Videos

Cocaine self-administration under variable-dose schedules in squirrel monkeys.

Leigh V Panlilio1, Eric B Thorndike, Charles W Schindler

  • 1Preclinical Pharmacology Section, Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, NIH, DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA. lpanlili@intra.nida.nih.gov

Pharmacology, Biochemistry, and Behavior
|July 4, 2006
PubMed
Summary

Squirrel monkeys self-administered cocaine, showing dose-effect curves sensitive to dopamine antagonists. Extended training led to dysregulated intake, which was restored by adding a timeout period, suggesting improved assessment of drug self-administration treatments.

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Area of Science:

  • Behavioral neuroscience
  • Psychopharmacology

Background:

  • Drug self-administration is a key model for studying addiction.
  • Understanding factors influencing drug intake is crucial for developing effective treatments.

Purpose of the Study:

  • To investigate cocaine self-administration in squirrel monkeys using a variable-dose schedule.
  • To assess the utility of this paradigm for evaluating pharmacological interventions.
  • To explore the mechanisms underlying drug intake dysregulation and recovery.

Main Methods:

  • Squirrel monkeys were trained to self-administer cocaine under a variable-dose schedule.
  • Dose-effect curves were generated by varying cocaine doses per injection.
  • The effects of dopamine antagonists on self-administration were examined.

Related Experiment Videos

  • A timeout period was introduced to address dysregulated drug intake.

    • Main Results:

    • Post-injection pauses monotonically varied with cocaine dose, allowing dose-effect curve generation.
    • Dopamine antagonist pretreatment shifted these dose-effect curves.
    • Prolonged training led to dysregulated intake, characterized by short pauses across all doses.
    • A 60-s timeout period restored dose-sensitivity.
    • Increasing the response requirement revealed dose-dependency in both pauses and post-pause responding ('run rates').

    Conclusions:

    • The variable-dose self-administration procedure is an efficient method for assessing treatments affecting cocaine intake.
    • Drug intake dysregulation can occur with extensive training but is reversible.
    • Timeout periods can mitigate dysregulation, possibly by ensuring adequate drug distribution.
    • Both motivational and direct drug effects influence responding patterns in this paradigm.