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Updated: Jul 28, 2026

The Attentional Set Shifting Task: A Measure of Cognitive Flexibility in Mice
Published on: February 4, 2015
Set shifting deficits in melancholic vs. non-melancholic depression: preliminary findings
I Michopoulos1, I M Zervas, V M Papakosta
12nd Department of Psychiatry, Athens University Medical School, Attikon General Hospital, 1 Rimini Street, 124 62 Athens, Greece. panpsyclin@attikonhospital.gr
Abstract:
Twenty-two patients with major depressive disorder, 11 of them with melancholic features, and 11 controls were investigated with CANTAB subtests focusing in visual memory/learning and executive functions. Melancholic patients performed worse than the other groups in all tasks and manifested a significant impairment in set shifting. The results are discussed in association with prefrontal dysfunction.
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