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Updated: Aug 7, 2026
09:07
Detecting the Ligand-binding Domain Dimerization Activity of Estrogen Receptor Alpha Using the Mammalian Two-Hybrid Assay
Published on: December 19, 2018
Tetrahydrofluorenones with conformationally restricted side chains as selective estrogen receptor beta ligands
Kenneth J Wildonger1, Ronald W Ratcliffe, Ralph T Mosley
1Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA. ken_wildonger@merck.com
Bioorganic & Medicinal Chemistry Letters
|July 4, 2006
Abstract:
A series of 2-9a bridged tetrahydrofluorenone derivatives were prepared which exhibited significant binding affinity for ERbeta and were highly selective.
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