Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Diabetes, leukoencephalopathy and rage.

Cory Toth1, Ann Marie Schmidt, Ursula I Tuor

  • 1Department of Clinical Neurosciences and the Neuroscience Research Group, University of Calgary, Alberta, Canada. corytoth@shaw.ca

Neurobiology of Disease
|July 4, 2006
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Real Time Pulse Chase (RTPC) In-Cell NMR Spectroscopy Reveals Critical Metabolites in Subminute Metabolism of Undifferentiated and Differentiated Human Neuronal Cells.

Analytical chemistry·2026
Same author

EXPRESS: RAGE in neutrophils triggers cerebral vasospasm in the hyperacute phase after subarachnoid hemorrhage.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same author

RAGE Re-Expressed at Myofibre Level Drives Muscle Wasting in Cancer Conditions.

Journal of cachexia, sarcopenia and muscle·2026
Same author

<i>ATVB</i> Journal Awards at Vascular Discovery.

Arteriosclerosis, thrombosis, and vascular biology·2026
Same author

Remembering Dr Janet T. Powell.

Arteriosclerosis, thrombosis, and vascular biology·2026
Same author

Joint modeling of longitudinal biomarker and survival outcomes with the presence of competing risk in the nested case-control studies with application to the TEDDY microbiome dataset.

Bioinformatics (Oxford, England)·2026

Longstanding diabetes mellitus causes brain white matter damage and cognitive decline in mice. This novel model highlights the role of receptor for advanced glycation end products (RAGE) signaling in diabetic neurodegeneration.

Area of Science:

  • Neuroscience
  • Endocrinology
  • Medical Imaging

Background:

  • Diabetes mellitus commonly affects kidneys, eyes, nerves, and blood vessels.
  • The brain, particularly white matter, is not typically considered a primary target of diabetic complications.
  • Existing models do not fully capture long-term cerebral changes in diabetes.

Purpose of the Study:

  • To establish and characterize a novel mouse model of long-term experimental diabetes.
  • To investigate direct brain involvement, focusing on white matter changes.
  • To explore the role of receptor for advanced glycation end products (RAGE) signaling in diabetic brain pathology.

Main Methods:

  • Long-term (9 months) experimental diabetes induction in mice.
  • Magnetic resonance (MR) imaging for in vivo assessment of brain structure.

Related Experiment Videos

  • Quantitative histological analysis of brain tissue.
  • Behavioral testing to assess cognitive function.
  • Assessment of RAGE expression in different brain regions and cell types.

    • Main Results:

    • Diabetic mice developed leukoencephalopathy and cerebral atrophy, mirroring human diabetic brain changes.
    • Cognitive deficits correlated with the duration of diabetes.
    • Increased RAGE expression was observed in white matter lesions and in grey and white matter cells.
    • RAGE-null diabetic mice exhibited significantly reduced neurodegenerative changes compared to wild-type diabetic mice.

    Conclusions:

    • Long-term diabetes directly impacts the brain, particularly white matter, in a novel mouse model.
    • Abnormal RAGE signaling is a key mediator of neurodegeneration in experimental diabetes.
    • This model provides new insights into the mechanisms of diabetic encephalopathy and potential therapeutic targets.