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Updated: Dec 24, 2025

Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System
Published on: September 20, 2019
Cytokines and chemokines orchestrate atopic skin inflammation
Bernhard Homey1, Martin Steinhoff, Thomas Ruzicka
1Department of Dermatology, Heinrich-Heine-University, Moorenstrasse 5, Düsseldorf 40225, Germany. Bernhard.Homey@uni-duesseldorf.de
Abstract:
Atopic dermatitis (AD) is a common pruritic and chronically relapsing inflammatory skin disease. The pathophysiology of AD includes disturbed skin barrier functions, frequent allergic responses against allergens, defects in the antimicrobial immune defense, and a genetic predisposition. In this review we summarize advances in our understanding of the complex interdependent network of members of the rapidly growing protein superfamilies of cytokines and chemokines that lead to the development of AD.
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