Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Estrogen blockade reduces auditory feedback in CBA mice.

Scott K Thompson1, Xiaoxia Zhu, Robert D Frisina

  • 1Department of Otolaryngology-Head and Neck Surgery, University of Rochester School of Medicine and Dentistry, 973 East Avenue, Rochester, NY 14607, USA. scott_thompson@urmc.rochester.edu

Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
|July 4, 2006
PubMed
Summary

Estrogen suppression negatively impacts auditory function by impairing contralateral suppression (CS) of distortion product otoacoustic emissions (DPOAEs) in aging mice, suggesting estrogen

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Short-Term Neurobehavioral Effects of Acute Respiratory Illness on Auditory-Motor Integration During Speech Production.

Journal of speech, language, and hearing research : JSLHR·2026
Same author

The quality evaluation of information in hospice and palliative care short videos on Douyin (TikTok's Chinese version) and Bilibili: a cross-sectional study.

Frontiers in digital health·2026
Same author

Application effect of a traceability management system in the centralized reprocessing of orthopedic loaned medical instruments: A retrospective comparative study.

Medicine·2026
Same author

An Adhesive Powder Based on Sodium Carboxymethyl Cellulose and Polyacrylic Acid for Efficient Hemostasis.

ACS applied bio materials·2026
Same author

Orelabrutinib for systemic lupus erythematosus: A randomised, double-blind, placebo-controlled study.

Journal of autoimmunity·2026
Same author

Correlation Between the Portal Venous Wall Shear Stress Using Ultrasound Vector Flow Imaging and Liver Regeneration in Rats With Portal Vein Stenosis.

Ultrasound in medicine & biology·2026

Area of Science:

  • Otoacoustic emissions research
  • Auditory neuroscience
  • Endocrinology

Background:

  • Age-related hearing loss is a growing concern.
  • Estrogen's role in auditory function is not fully understood.
  • Distortion product otoacoustic emissions (DPOAEs) and contralateral suppression (CS) are key indicators of cochlear health and efferent system function.

Purpose of the Study:

  • To investigate the impact of estrogen suppression on age-related changes in DPOAEs and CS.
  • To determine if estrogen deficiency affects the medial olivocochlear (MOC) efferent feedback system.

Main Methods:

  • Young CBA mice were treated with tamoxifen (estrogen suppressor) or placebo via slow-release implants.
  • DPOAEs and CS were measured serially over 9 weeks.

Related Experiment Videos

  • Age-related changes were compared between groups, including untreated male mice.

    • Main Results:

    • DPOAEs remained stable in all groups throughout the study.
    • CS of DPOAEs significantly decreased with age in estrogen-suppressed mice.
    • No age-related decline in CS was observed in control or male mice.

    Conclusions:

    • Estrogen suppression adversely affects the MOC efferent feedback system.
    • Estrogen is crucial for maintaining auditory integrity.
    • Findings suggest potential auditory implications of hormonal changes in humans, including menopause and hormone therapies.