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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Infections and cardiovascular disease in patients with chronic kidney disease

Robert N Foley1

  • 1Chronic Disease Research Group, University of Minnesota, Minneapolis, MN 55404, USA. RFoley@cdrg.org

Advances in Chronic Kidney Disease
|July 4, 2006
PubMed

Insights

Major infections are linked to cardiovascular events in dialysis patients. Further research is needed to explore the prognostic implications of infections in non-dialysis chronic kidney disease (CKD) patients.

Area of Science:

  • Nephrology
  • Cardiology
  • Infectious Diseases

Background:

  • Growing interest in the chronic kidney disease (CKD) and cardiovascular disease (CVD) link.
  • Limited research on CKD-related infections despite links between inflammation, kidney, and heart disease.
  • Major infections like pneumonia and septicemia are inflammatory states linked to cardiovascular events in dialysis patients.

Purpose of the Study:

  • To highlight the modest research activity in CKD-related infections.
  • To underscore the association between infections and cardiovascular events in dialysis patients.
  • To investigate the prognostic implications of major infections in non-dialysis CKD patients.

Main Methods:

  • Review of existing literature on CKD, CVD, and infections.
  • Analysis of epidemiological data on infection rates in CKD populations.
  • Exploration of the prognostic impact of infections on cardiovascular outcomes.

Main Results:

  • Significant increase in research on CKD and CVD nexus.
  • Modest research activity concerning CKD-related infections.
  • Established link between major infections and adverse cardiovascular events/mortality in dialysis patients.
  • Higher hospitalization rates for infections in non-dialysis CKD patients compared to the general population.

Conclusions:

  • The association between major infections and cardiovascular events is well-documented in dialysis patients.
  • The prognostic implications of infections in non-dialysis CKD patients remain largely unexplored.
  • Further research is warranted to understand the impact of infections on cardiovascular outcomes in the broader CKD population.

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