Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Malignant hereditary paraganglioma: problems raised by non-functional forms management].

S Bonnet1, X Durand, O Baton

  • 1Service de Chirurgie Viscérale et Vasculaire, Hôpital d'Instruction des Armées du Val-de-Grâce, 74, boulevard de Port-Royal, 75230 Paris cedex 05, France. stephanebonnet@caramail.com

Annales De Chirurgie
|July 4, 2006
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characteristics, management, and outcomes of patients with VIPoma-A retrospective analysis of the ENETS database.

Journal of neuroendocrinology·2026
Same author

Streptozotocin plus 5-fluorouracil followed by everolimus or the reverse sequence in patients with advanced pancreatic neuroendocrine tumors (SEQTOR-GETNE phase III study): a randomized clinical trial.

ESMO open·2025
Same author

Time-domain braiding of anyons.

Science (New York, N.Y.)·2025
Same author

Proof of concept and design of an externally controlled trial for patients with gastro-enteropancreatic neuroendocrine carcinomas based on the randomized phase II BEVANEC trial.

European journal of cancer (Oxford, England : 1990)·2025
Same author

Time-resolved sensing of electromagnetic fields with single-electron interferometry.

Nature nanotechnology·2025
Same author

Neuroendocrine neoplasms of head and neck, genitourinary and gynaecological systems, unknown primaries, parathyroid carcinomas and intrathyroid thymic neoplasms: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up.

ESMO open·2024

Non-functional paragangliomas often present late due to lack of distinct features. Hereditary forms, like those with SDHB mutations, benefit from genetic testing for earlier diagnosis and management.

Area of Science:

  • Endocrinology
  • Oncology
  • Genetics

Background:

  • Non-functional paragangliomas lack specific clinical or biological markers, leading to delayed diagnosis.
  • Diagnosis often occurs incidentally during management of advanced abdominal tumors or symptomatic metastases.

Observation:

  • Hereditary paragangliomas, particularly those with succinate dehydrogenase B (SDHB) mutations, are associated with a poorer prognosis.
  • Unlike sporadic forms, hereditary paragangliomas are candidates for genetic testing.

Findings:

  • Genetic testing in hereditary paragangliomas enables earlier diagnosis before symptom onset, recurrence, or metastasis.
  • This case highlights a non-functional malignant hereditary paraganglioma diagnosed late, underscoring diagnostic challenges.

Related Experiment Videos

Implications:

  • Early diagnosis through genetic screening can significantly alter the management and prognosis of hereditary paragangliomas.
  • Addressing management challenges in non-functional paraganglioma is crucial for improving patient outcomes.