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Updated: Aug 7, 2026
In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
Published on: July 24, 2020
Evaluation of macular changes before and after successful retinal detachment surgery using stratus-optical coherence
Amélie Lecleire-Collet1, Marc Muraine, Jean-François Ménard
1Department of Ophthalmology, Rouen University Hospital-Charles Nicolle, Rouen, France. colletamelie@hotmail.com
Purpose:
To assess preoperative and postoperative infra-clinical macular changes in macula-off retinal detachment (RD) using third-generation optical coherence tomography (OCT3).
Design:
Prospective observational cohort study.
Methods:
Twenty-two nonconsecutive eyes of 22 patients with macula-off RD underwent best-corrected visual acuity measurement and OCT3 scans through the fovea before and after successful surgery. The relationship between preoperative and postoperative OCT macular characteristics, postoperative infra-clinical foveal detachment, and final visual acuity (FVA) were assessed using Kruskal-Wallis multiple comparison test and Mann-Whitney U test, respectively.
Results:
Preoperative cystic cavities in the inner nuclear layer of the detached retina, postoperative abnormal macular profile, and postoperative lack of the junction line between photoreceptor cell inner and outer segments on OCT3 were associated with a poorer FVA (P = .001, P = 10(-4) and P = .015, respectively). In contrast, postoperative infra-clinical foveal detachment did not influence FVA (P = .88).
Conclusions:
Morphologic macular analysis using OCT3 provide some new insights to understand incomplete visual recovery after successful macula-off RD surgery.