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The effect of adenosine 5'-triphosphate on calcium mobilization and cell proliferation in cervical cancer cells
Seok Geun Lee1, Jung-Kyoung Choi, Byung Hyune Choi
1Catholic Neuroscience Center, Catholic Research Institutes of Medical Science, College of Medicine, The Catholic University of Korea, Seoul 137-701, Republic of Korea.
Objective:
To know the effect of adenosine 5'-triphosphate (ATP) on intracellular calcium level and cell proliferation in cervical cancer cells.
Study Design:
Four different human cervical cancer cell lines (Caski, C33A, HeLaS3 and SiHa) were used in this study. The change of intracellular calcium level, cell proliferation and the activity of proliferation- and calcium-related transcription factors by extracellular ATP were examined in these cell lines.
Results:
Extracellular ATP induced calcium mobilization, cell proliferation and the activation of NF-kappaB in all cell lines used.
Conclusion:
These results suggest that calcium mobilization and NF-kappaB dependent signaling pathway play an important role in the cell proliferation by ATP in cervical cancer.
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