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Updated: Aug 7, 2026

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
Published on: April 18, 2025
Frontal dysfunction underlies depressive syndrome in Alzheimer disease: a FDG-PET study
Dong Young Lee1, Il Han Choo, Jin Hyeong Jhoo
1Department of Neuropsychiatry and Clinical Research Institute, Seoul National University, Seoul, Korea.
Objective:
This study aimed to investigate the regional cerebral dysfunction associated with depressive syndrome in patients with Alzheimer disease (AD).
Method:
Twelve patients with AD with depressive syndrome (ADD) and 12 age-, gender-, and severity-matched patients with AD without depressive syndrome (ADND) underwent FDG-PET scanning. The regional cerebral glucose metabolism in the two groups was compared using a voxel-based method.
Results:
The ADD group showed lower glucose metabolism in the right superior frontal gyrus than the ADND group.
Conclusions:
These results indicate that frontal dysfunction, known to be associated with primary or other secondary depressive syndromes, underlies the depressive syndrome of patients with AD patients as well.
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