Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Common genetic polymorphisms affect the human requirement for the nutrient choline.

Kerry-Ann da Costa1, Olga G Kozyreva, Jiannan Song

  • 1Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, CB# 7461, Chapel Hill, North Carolina 27599, USA.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
|July 4, 2006
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Choline and betaine concentrations in plasma discriminate levels of dietary choline intake in healthy adults: analysis of a double-blind randomized crossover controlled feeding study.

The American journal of clinical nutrition·2026
Same author

Pediatric severe sepsis: epidemiology and risk factors associated with acute kidney injury.

Frontiers in pediatrics·2026
Same author

Effects of varying inhaled oxygen concentrations on lung function in older adult patients undergoing laparoscopic gastrointestinal surgery under general anesthesia: protocol of a prospective multicenter clinical study in China.

Trials·2026
Same author

Choline and betaine concentrations in plasma predict dietary choline intake in healthy humans: a double-blind randomized control feeding study.

medRxiv : the preprint server for health sciences·2025
Same author

HLA DQA1*05 and Risk of Antitumor Necrosis Factor Treatment Failure and Anti-Drug Antibody Development in Children With Crohn's Disease.

The American journal of gastroenterology·2025
Same author

Basic research on postoperative cognitive dysfunction in the past decade: a bibliometric analysis.

Frontiers in aging neuroscience·2025

Genetic variations in choline metabolism influence how much of this essential nutrient individuals need. Certain single nucleotide polymorphisms (SNPs) increase the risk of organ dysfunction when choline intake is low.

Area of Science:

  • Nutritional Science
  • Human Genetics
  • Biochemistry

Background:

  • Choline is an essential nutrient vital for human health.
  • Dietary choline deficiency can lead to organ dysfunction.
  • Genetic factors may influence individual choline requirements.

Purpose of the Study:

  • To investigate the association between single nucleotide polymorphisms (SNPs) in choline metabolism genes and susceptibility to choline deficiency.
  • To determine if common genetic variants affect the dietary requirement for choline.

Main Methods:

  • Fifty-seven participants were placed on a controlled low-choline diet.
  • DNA was analyzed for single nucleotide polymorphisms (SNPs) in genes related to choline metabolism.
  • Allelic association was tested between SNPs and the development of organ dysfunction.

Related Experiment Videos

Main Results:

  • An SNP in the phosphatidylethanolamine N-methyltransferase (PEMT) gene promoter (rs12325817) significantly increased susceptibility to choline deficiency (OR=25, P=0.002).
  • A variant in the choline dehydrogenase (CHDH) gene (rs9001) showed a protective effect, while another (rs12676) increased susceptibility.
  • SNPs in PEMT coding region and BHMT were not associated with choline deficiency susceptibility.

Conclusions:

  • Common genetic polymorphisms in choline metabolism genes influence individual dietary requirements for choline.
  • Identifying individuals with specific SNPs can help tailor recommendations for adequate choline intake.
  • This research aids in personalized nutrition strategies to prevent choline deficiency-related health issues.