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New antiviral agents.
Nahed Abdel-Haq1, Pimpanada Chearskul, Hossam Al-Tatari
1Division of Infectious Diseases, Children's Hospital of Michigan, Carman and Ann Adams, Department of Pediatrics, Wayne State University, School of Medicine, Detroit 48201, USA. nabdel@dmc.org
Indian Journal of Pediatrics
|July 4, 2006
Summary
Recent advances in understanding viral replication have led to new antiviral drugs for herpes simplex virus (HSV), varicella-zoster virus (VZV), cytomegalovirus (CMV), and human papillomavirus (HPV). This review covers newer systemic and topical agents like famciclovir and imiquimod.
Area of Science:
- Virology and Pharmacology
- Infectious Diseases
Background:
- Significant progress in understanding viral replication mechanisms over 30 years.
- Viral infections like herpes simplex virus (HSV), varicella-zoster virus (VZV), cytomegalovirus (CMV), and human papillomavirus (HPV) pose significant health challenges.
- Development of novel antiviral therapies with improved efficacy and safety profiles.
Purpose of the Study:
- To review recent advancements in systemic and topical antiviral agents.
- To focus on treatments for HSV-1, HSV-2, VZV, CMV, and HPV infections.
- To highlight key antiviral drugs including famciclovir, penciclovir, valganciclovir, imiquimod, docosanol, and brivudine.
Main Methods:
- Literature review of antiviral agents developed in the last three decades.
- Focus on agents targeting herpesviruses and human papillomavirus.
- Analysis of systemic and topical treatment options.
Main Results:
- Identification of newer antiviral agents with enhanced activity and tolerability.
- Categorization of agents based on their application (systemic vs. topical).
- Specific mention of famciclovir, penciclovir, valganciclovir, imiquimod, docosanol, and brivudine as key treatments.
Conclusions:
- The last three decades have seen substantial improvements in antiviral therapies.
- Newer agents offer better treatment outcomes for various viral infections.
- Continued research is crucial for developing even more effective antiviral strategies.