Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Operant methods for mouse psychoacoustics.

Karin B Klink1, Garnet Bendig, Georg M Klump

  • 1Carl von Ossietzky Universität Oldenburg, Oldenburg, Germany.

Behavior Research Methods
|July 5, 2006
PubMed
Summary

The constant-stimuli procedure, combined with signal detection theory, offers more accurate and reliable auditory sensory threshold measurements in mice compared to adaptive-tracking methods. This psychoacoustic approach provides lower and less variable tone detection thresholds.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Auditory perception and neural representation of temporal features are altered by age but not by cochlear synaptopathy.

eLife·2026
Same author

Establishing Reference Values in Healthy Participants for the Cardiac Troponin T High-Sensitivity Gen 6 Assay: REF-TSIX Global Reference Study.

Clinical chemistry·2026
Same author

Clinical performance of the next generation Elecsys Troponin T high-sensitivity Gen 6 assay in acute coronary syndrome (PERFORM-TSIX): study design.

Clinical research in cardiology : official journal of the German Cardiac Society·2026
Same author

Degeneration of the stria vascularis in quiet-aged gerbils: Linking structural, cellular and molecular changes to cochlear function.

Neurobiology of aging·2025
Same author

The Stria Vascularis: Renewed Attention on a Key Player in Age-Related Hearing Loss.

International journal of molecular sciences·2024
Same author

Cochlear Ribbon Synapses in Aged Gerbils.

International journal of molecular sciences·2024

Area of Science:

  • Auditory Neuroscience
  • Psychoacoustics
  • Animal Models

Background:

  • Determining auditory sensory thresholds is crucial for understanding hearing function.
  • Psychoacoustic methods are essential for quantifying auditory perception in animal models.
  • Comparing different psychophysical procedures is necessary to optimize threshold determination.

Purpose of the Study:

  • To compare the efficacy of the constant-stimuli procedure versus the two-down/one-up adaptive-tracking procedure for determining auditory sensory thresholds.
  • To evaluate the influence of threshold criteria and signal detection theory on threshold measurements.
  • To identify the most accurate and reliable method for measuring tone detection thresholds in NMRI mice.

Main Methods:

  • Psychoacoustic experiments were conducted on NMRI mice using a 10-kHz tone.

Related Experiment Videos

  • Both constant-stimuli and adaptive-tracking procedures were applied to the same subjects.
  • Thresholds were determined using identical criteria (70.7% response probability) and analyzed with signal detection theory (d' = 1).

    • Main Results:

    • Constant-stimuli thresholds were significantly lower (average 24 dB) and less variable than adaptive-tracking thresholds.
    • Reducing trials in the constant-stimuli procedure from 100 to 50 minimally impacted accuracy.
    • Optimal results were achieved with the constant-stimuli procedure using signal detection theory (d' = 1).

    Conclusions:

    • The constant-stimuli procedure, particularly when combined with signal detection theory, is superior to adaptive-tracking for determining auditory sensory thresholds in mice.
    • This method provides more precise and consistent measurements of auditory sensitivity.
    • The findings support the use of constant-stimuli with signal detection theory for robust auditory threshold assessment.