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Published on: July 20, 2022
Abnormalities of left atrial function after cardioversion: an atrial strain rate study
1Department of Cardiology, University of Sydney/Westmead Hospital, Darcy Road, Sydney 2145, New South Wales, Australia. lizat@westgate.wh.usyd.edu.au
Insights
Atrial myocardial dysfunction after cardioversion for chronic atrial fibrillation (CAF) is measurable using atrial strain rate (A-sr). This measure, though initially reduced, shows recovery over time in patients with CAF.
Area of Science:
- Cardiology
- Echocardiography
- Cardiac Physiology
Background:
- Atrial myocardial dysfunction post-cardioversion for chronic atrial fibrillation (CAF) requires further elucidation.
- The utility of Doppler-derived atrial strain rate (A-sr) in assessing global left atrial function after cardioversion is not well-defined.
Purpose of the Study:
- To evaluate Doppler-derived atrial strain rate (A-sr) as a measure of global left atrial function.
- To compare A-sr in patients with CAF post-cardioversion against healthy controls.
- To assess changes in A-sr over a 6-month follow-up period.
Main Methods:
- Measured A-sr from four atrial walls using Doppler tissue imaging in 37 cardioverted CAF patients and 37 controls.
- Assessed conventional atrial function parameters and atrial contraction velocity (A' velocity).
- Measured time to peak A-sr from aortic valve closure.
Main Results:
- Immediately post-cardioversion, A-sr was significantly lower in the CAF group compared to controls (p<0.001).
- A-sr correlated with A' velocity (r = 0.63; p<0.001) in patients.
- Atrial function improved within 4 weeks, but the time to peak A-sr remained prolonged compared to controls.
Conclusions:
- Doppler-derived atrial strain rate (A-sr) effectively quantifies global left atrial function.
- Atrial function, assessed by A-sr, is impaired after cardioversion from CAF but demonstrates recovery.
- While overall function improves, prolonged time to peak A-sr suggests persistent subtle dysfunction.
Background And Objectives:
The role of atrial myocardial dysfunction after cardioversion is unclear. In a comparison of patients after successful cardioversion from chronic atrial fibrillation (CAF) and normal controls, we sought to determine whether Doppler-derived atrial strain rate (A-sr) could be used to measure global left atrial function and whether A-sr was reduced in patients with CAF.
Methods:
A-sr was measured from the basal septal, lateral, inferior and anterior atrial walls from the apical four-chamber and two-chamber views in 37 patients with CAF who had been cardioverted to sinus rhythm and followed up for 6 months, and in a cohort of 37 healthy people. Conventional measures of atrial function included peak transmitral A-wave velocity, A-wave velocity time integral, atrial fraction and the left atrial ejection fraction. Doppler tissue imaging was used to estimate atrial contraction velocity (A' velocity). In addition to amplitude parameters, the time to peak A-sr was measured from aortic valve closure.
Results:
Immediately after cardioversion, A-sr in the CAF cohort (baseline) was significantly lower than in controls (mean (SD) -0.53 (0.31) v -1.6 (0.75) s(-1); p<0.001); the A-sr correlated with A' velocity (r = 0.63; p<0.001) in patients. Atrial function improved over time, with maximal change observed in the initial 4 weeks after cardioversion. The time to peak A-sr was increased in the CAF group compared with controls (0.55 (0.15) v 0.46 (0.12) s), but this failed to normalise over time.
Conclusion:
A-sr is a descriptor of atrial function, which is reduced after cardioversion from CAF and subsequently recovers.
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