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Treatment of chronic hepatitis B in children

Maureen M Jonas1

  • 1Children's Hospital, and Harvard Medical School, Boston, MA 02115, USA.

Journal of Pediatric Gastroenterology and Nutrition
|July 5, 2006
PubMed

Insights

Chronic hepatitis B is a global health issue, often acquired in childhood. This article reviews treatment options for children with chronic hepatitis B, including current and emerging therapies.

Area of Science:

  • Hepatology
  • Pediatric Infectious Diseases
  • Virology

Background:

  • Chronic hepatitis B infection acquired in infancy or childhood leads to significant global morbidity.
  • Pediatric chronic hepatitis B infection presents unique challenges in management and treatment.
  • Antiviral therapy is increasingly considered for select pediatric cases.

Purpose of the Study:

  • To outline the rationale for treating chronic hepatitis B in children.
  • To define patient selection criteria for pediatric hepatitis B treatment.
  • To review current and future therapeutic options for pediatric chronic hepatitis B.

Main Methods:

  • Literature review of current treatment guidelines for pediatric hepatitis B.
  • Analysis of existing and emerging antiviral medications for children.
  • Discussion of the advantages and disadvantages of various treatment strategies.

Main Results:

  • Two antiviral medications are currently approved for pediatric use.
  • Additional therapeutic options are expected to become available soon.
  • Treatment decisions require careful consideration of individual patient factors.

Conclusions:

  • Treatment of chronic hepatitis B in children is evolving, with more options anticipated.
  • Careful patient selection is crucial for successful pediatric hepatitis B management.
  • Understanding the pros and cons of available therapies is essential for clinicians.

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