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Published on: February 10, 2015
Liver involvement in Langerhans cell histiocytosis
Adelaine Wong1, Clara L Ortiz-Neira, Walid Abou Reslan
1Department of Diagnostic Imaging, Alberta Children's Hospital, 1820, Richmond Road S.W., Calgary, Alberta, T2T 5C7, Canada.
Abstract:
Liver involvement in Langerhans cell histiocytosis (LCH) typically presents with hepatomegaly and other signs of liver dysfunction. We present an 11-month-old child having only minimally elevated liver enzymes as an indication of liver involvement. Using sonography as the initial diagnostic tool followed by MRI, LCH of the liver was revealed. A review of sonographic, CT, MRI and MR cholangiopancreatography findings in liver LCH is presented. We recommend that physicians consider sonography and MRI screening for liver involvement in patients with newly diagnosed LCH, as periportal involvement may be present with little or no liver function abnormality present, as in this patient.
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