Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vesicle pools, docking, priming, and release.

Ute Becherer1, Jens Rettig

  • 1Universität des Saarlandes, Physiologisches Institut, Gebäude 59, Kirrberger Strasse 8, 66421, Homburg/Saar, Germany.

Cell and Tissue Research
|July 5, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lytic IFNγ is stored in cytotoxic granules and coreleased with granzyme B to mediate cytotoxic T lymphocyte killing.

Cellular & molecular immunology·2026
Same author

T-Cell-Derived Exosomes From Multi Core Granules Exhibit Superior Caspase-3-Mediated Tumor-Suppressive Activity Compared to Those From Multivesicular Bodies.

Journal of extracellular vesicles·2026
Same author

IFNγ Expression Correlates with Enhanced Cytotoxicity in CD8+ T Cells.

International journal of molecular sciences·2025
Same author

Highly adaptable deep-learning platform for automated detection and analysis of vesicle exocytosis.

Nature communications·2025
Same author

Correction: Required minimal protein domain of flower for synaptobrevin2 endocytosis in cytotoxic T cells.

Cellular and molecular life sciences : CMLS·2025
Same author

Activation-induced thrombospondin-4 works with thrombospondin-1 to build cytotoxic supramolecular attack particles.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same journal

Correction to: Integrated morphological analyses of Cladomorphus phyllinus and transcriptomic analysis of Cladomorphus trimariensis provide insights into the cardiac morphophysiology of stick insects (Phasmida: Phasmatidae).

Cell and tissue research·2026
Same journal

Deletion of CEACAM1 does not affect retinal and choroidal morphology or transcriptome.

Cell and tissue research·2026
Same journal

Cardiac α2δ1 C-terminal contributes to left atrial hypertrophy in chronic ischemic heart failure, in association with changes in membrane GluN1 and p-CAMKII/p-HDAC4 signaling.

Cell and tissue research·2026
Same journal

Gill ionocytes of the Lake Magadi tilapia (Oreochromis Alcolapia grahami), an extremophilic teleost native to a highly alkaline environment.

Cell and tissue research·2026
Same journal

Integrated morphological analyses of Cladomorphus phyllinus and transcriptomic analysis of Cladomorphus trimariensis provide insights into the cardiac morphophysiology of stick insects (Phasmida: Phasmatidae).

Cell and tissue research·2026
Same journal

Effects of gestational protein restriction on autophagy dynamics during odontogenesis.

Cell and tissue research·2026
See all related articles

Synaptic vesicles mature through docking and priming before neurotransmitter release. This review defines vesicle pools and the proteins regulating their transitions for effective synaptic signaling.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Biochemistry

Background:

  • Neurotransmitter release from synaptic vesicles is crucial for neuronal communication.
  • Synaptic vesicle maturation involves docking and priming before fusion.
  • Distinct vesicle pools exist based on their readiness for fusion.

Purpose of the Study:

  • To define the different synaptic vesicle pools.
  • To discuss the pathways regulating transitions between these pools.
  • To review proteins involved in vesicle pool dynamics.

Main Methods:

  • Literature review of physiological and optical experiments.
  • Analysis of high-time resolution studies on vesicle fusion.
  • Compilation of identified and speculated proteins in vesicle maturation.

Related Experiment Videos

Main Results:

  • Synaptic vesicles exist in distinct pools (e.g., readily releasable, recycling, reserve).
  • Pathways into and out of these pools involve complex regulatory mechanisms.
  • Numerous proteins are implicated in docking, priming, and fusion processes.

Conclusions:

  • Understanding vesicle pools and their regulation is key to synaptic transmission.
  • Protein involvement in vesicle pool transitions is critical for neuronal signaling.
  • Further research on these proteins will elucidate synaptic function and dysfunction.