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Updated: Aug 7, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction
Published on: November 3, 2011
Analysis of conserved hydrophobic cores in proteins and supramolecular complexes
Anna Karyagina1, Anna Ershova, Mikhail Titov
1Gamaleya Institute of Epidemiology and Microbiology, Gamaleya Str. 18, Moscow 123098, Russia. akaryagina@rambler.ru
Abstract:
The conserved hydrophobic core is an important feature of a family of protein domains. We suggest a procedure for finding and the analysis of conserved hydrophobic cores. The procedure is based on using an original program called CluD (http://monkey.belozersky.msu.ru/CluD/cgi-bin/hftri.pl). Conserved hydrophobic cores of several families including homeodomains and interlock-containing domains are described. Hydrophobic clusters on some protein-DNA and protein-protein interfaces were also analyzed.
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