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Choroid plexus carcinoma in a goat.
R Klopfleisch1, D Beier, J P Teifke
1Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, 17493 Greifswald-InselRiems, Germany.
Journal of Comparative Pathology
|July 6, 2006
Summary
A rare choroid plexus carcinoma was diagnosed in a goat, causing obstructive hydrocephalus and neurological signs. This case highlights the importance of considering such neoplasms in caprine neurological disease.
Area of Science:
- Veterinary Pathology
- Comparative Oncology
- Neuropathology
Background:
- Choroid plexus tumors are rare intracranial neoplasms.
- Neoplasms of the central nervous system in goats are infrequently reported.
- Head tilting and neurological deficits can indicate serious brain pathology in goats.
Purpose of the Study:
- To report the first documented case of choroid plexus carcinoma in a goat.
- To describe the clinical, post-mortem, and histopathological findings.
- To characterize the immunohistochemical profile of the tumor cells.
Main Methods:
- Gross post-mortem examination of the brain.
- Histopathological evaluation of the intraventricular neoplasm.
- Immunohistochemical staining for vimentin, cytokeratins, GFAP, NSE, and S100 antigen.
Main Results:
- A large, unilateral intraventricular neoplasm was identified, diagnosed as choroid plexus carcinoma.
- The tumor caused obstructive hydrocephalus and invaded adjacent brain tissue.
- Tumor cells expressed vimentin and cytokeratins, but not GFAP, NSE, or S100.
Conclusions:
- Choroid plexus carcinoma is a potential diagnosis for goats presenting with neurological signs.
- This case expands the known spectrum of central nervous system neoplasms in goats.
- Further research into caprine brain tumors is warranted.