Parameterization, comparison, and validation of models quantifying relative change of cuticular permeability with
1Lancaster Environment Centre/Biological Sciences, Lancaster University, Lancaster LA1 4YQ, UK. g.kerstiens@lancaster.ac.uk
Abstract:
Predictions from two previously published models and a new model for the relative change in cuticular permeability with boiling point, octanol/air partition coefficient, and/or molar volume of a wide range of diffusants (not including ions and large hydrophilic compounds) are compared with each other and to experimental data sets not used for model parameterization. While the models work in a similar way for all cuticles for which data are available, it is not yet possible to predict in absolute terms the permeability of any cuticles for which no data are available-that is, while the slope of a plot representing the change in permeability with diffusant properties is predictable, the position of the linear relationship along the ordinate needs to be determined experimentally for each type of cuticle at or near the relevant temperature(s).
Related Concept Videos
Pharmacokinetic Models: Comparison and Selection Criterion
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
In Vitro Drug Dissolution: Compendial Testing Models II
Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models
Theories of Dissolution: The Danckwerts' Model and Interfacial Barrier Model
Two-Compartment Open Model: Extravascular Administration
The absorption exponent (ka) indicates the speed at which the drug is...
Model Approaches for Pharmacokinetic Data: Physiological Models

