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Related Concept Videos

Heart Valves01:16

Heart Valves

The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...

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Related Experiment Video

Updated: Jul 20, 2026

Directed Cellular Self-Assembly to Fabricate Cell-Derived Tissue Rings for Biomechanical Analysis and Tissue Engineering
08:00

Directed Cellular Self-Assembly to Fabricate Cell-Derived Tissue Rings for Biomechanical Analysis and Tissue Engineering

Published on: November 25, 2011

Pulsatile myocardial tubes fabricated with cell sheet engineering.

Hidekazu Sekine1, Tatsuya Shimizu, Joseph Yang

  • 1Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan.

Circulation
|July 6, 2006
PubMed
Summary

Engineered myocardial tubes, created using cell sheet technology, exhibit independent pulsations and potential for circulatory support. Host blood flow promotes cardiomyocyte growth, offering a novel approach for cardiac tissue engineering.

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Area of Science:

  • Regenerative Medicine
  • Cardiovascular Engineering
  • Biomaterials Science

Background:

  • Tissue engineering offers alternatives for treating damaged hearts.
  • Current methods focus on cardiac patch transplantation.
  • This study explores using cardiomyocyte sheets for myocardial tube creation.

Purpose of the Study:

  • To create pulsatile myocardial tubes using cell sheet engineering.
  • To evaluate the in vivo function and survival of these engineered tissues.
  • To investigate the potential for circulatory support and cardiac assistance.

Main Methods:

  • Neonatal rat cardiomyocyte sheets were used.
  • Sheets were wrapped around resected rat aorta to form myocardial tubes.
  • Tubes were transplanted into athymic rats to replace the abdominal aorta.

Main Results:

  • Transplanted myocardial tubes showed spontaneous, synchronous pulsations.
  • Independent graft pressures of 5.9+/-1.7 mm Hg were recorded.
  • Histology confirmed native-like cardiac tissue composition; enhanced thickness and specific protein expression were observed in aortic-grafted tubes compared to abdominal cavity grafts.

Conclusions:

  • Functional myocardial tubes capable of circulatory support can be engineered.
  • Pulsation from host blood flow stimulates cardiomyocyte hypertrophy and growth.
  • This demonstrates a novel method for developing engineered cardiac tissues for independent cardiac assistance.