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Genetic polymorphisms of eNOS, hormone receptor status, and survival of breast cancer

Ji-Yeob Choi1, Kyoung-Mu Lee, Dong-Young Noh

  • 1Department of Epidemiology, Roswell Park Cancer Institute, Buffalo, NY, USA.

Breast Cancer Research and Treatment
|July 6, 2006
PubMed

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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
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