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Related Experiment Videos

Chemotherapy-related arthropathy.

Mi-Jeong Kim1, Young-Min Ye, Hae-Sim Park

  • 1Department of Allergy-Rheumatology, Ajou University School of Medicine, Suwon, Korea.

The Journal of Rheumatology
|July 6, 2006
PubMed
Summary

Chemotherapy-related arthropathy, a condition causing joint pain and stiffness, is manageable. Early treatment with disease-modifying antirheumatic drugs (DMARDs) and corticosteroids often leads to symptom resolution.

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Corrigendum to "A peptide derived from the core β-sheet region of TIRAP decoys TLR4 and reduces inflammatory and autoimmune symptoms in murine models" [eBioMedicine 52 (2020) 102645].

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Area of Science:

  • Rheumatology
  • Oncology
  • Pharmacology

Background:

  • Cancer patients undergoing chemotherapy may develop joint pain and stiffness.
  • Chemotherapy-induced arthralgia can significantly impact patient quality of life.

Purpose of the Study:

  • To characterize the clinical presentation and outcomes of chemotherapy-related arthropathy.
  • To evaluate the efficacy of treatments for this condition.

Main Methods:

  • Retrospective chart review of 18 patients with cancer who developed joint symptoms post-chemotherapy.
  • Telephone interviews to assess current joint symptoms and treatment response.
  • Analysis of demographic data, cancer type, chemotherapy agents, and rheumatologic findings.

Main Results:

  • The most common agents linked to arthropathy were 5-fluorouracil, cyclophosphamide, and cisplatin.
  • Symptoms typically emerged 6 months post-chemotherapy, with patients reporting average of 8 tender joints and 6 hours of morning stiffness.
  • 14 of 15 patients showed significant improvement with disease-modifying antirheumatic drugs (DMARDs) and corticosteroids, with 9 achieving complete symptom resolution.

Conclusions:

  • Chemotherapy-related arthropathy is a notable side effect of certain cancer treatments.
  • Early intervention with DMARDs and corticosteroids generally yields favorable outcomes and symptom resolution.

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