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[Acne vulgaris: endocrine aspects].
O M Dekkers1, B H Thio, J A Romijn
1Leids Universitair Medisch Centrum, afd. Endocrinologie, Postbus 9600, 2300 RC Leiden. o.m.dekkers@lumc.nl
Nederlands Tijdschrift Voor Geneeskunde
|July 11, 2006
Summary
Androgens significantly contribute to acne vulgaris development, with local enzyme activity and androgen receptors playing key roles. Hormonal therapies target androgen production or receptor binding to manage acne.
Area of Science:
- Dermatology and Endocrinology
- Hormonal regulation of skin conditions
Context:
- Acne vulgaris is a common skin condition influenced by androgens.
- Elevated androgen levels are observed in acne patients compared to controls.
- Androgen insensitivity syndrome prevents acne development, highlighting androgen's role.
Purpose:
- To elucidate the role of androgens and local factors in acne vulgaris pathogenesis.
- To explore the mechanisms of hormonal anti-acne therapies.
Summary:
- Androgens are crucial in acne vulgaris development, not solely dependent on plasma levels.
- Local skin enzymes convert precursor hormones into potent androgens like testosterone and dihydrotestosterone.
- Acne can manifest as a symptom of endocrine disorders, notably polycystic ovary syndrome.
Impact:
- Understanding local androgen synthesis and receptor activity is vital for acne treatment.
- Hormonal therapies, such as estrogens or anti-androgens, offer effective acne management strategies.
- Identifies polycystic ovary syndrome as a significant comorbidity in persistent adult female acne.