Related Experiment Videos
Dermatological toxicity of ixabepilone
Alison K Conlin1, Linda Vahdat
1Division of Oncology, Department of Internal Medicine, New York-Presbyterian Weill Cornell Medical Center, New York, NY, USA.
Anticancer Research
|July 11, 2006
Summary
Ixabepilone, a microtubule-stabilizing agent, is used for breast cancer. A patient developed an unexpected skin reaction, highlighting a previously undocumented toxicity of this chemotherapy.
Area of Science:
- Oncology
- Pharmacology
Background:
- Ixabepilone is a novel non-taxane microtubule-stabilizing agent.
- It functions by binding tubulin, stabilizing microtubules, inhibiting mitosis, and inducing cancer cell death.
- Previous Phase I studies documented neutropenia, fatigue, anorexia, mucositis, neuropathy, myalgia, arthralgia, alopecia, and gastrointestinal toxicities.
Observation:
- A case report details a 62-year-old woman with stage 4 breast cancer undergoing Ixabepilone treatment (40 mg/m2).
- The patient experienced a dermatological reaction.
- This reaction was not previously documented as a toxicity associated with Ixabepilone therapy.
Findings:
- The study reports a novel dermatological adverse event associated with Ixabepilone.
- This finding expands the known toxicity profile of Ixabepilone.
Implications:
- This case highlights the importance of monitoring for and reporting rare adverse events.
- It may necessitate updates to the known side effect profile of Ixabepilone.
- Further investigation into Ixabepilone's dermatological toxicities is warranted.
Related Concept Videos
01:26Toxic Reactions: Overview
2.1K
When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
2.1K
01:21Frequency-dependent Selection
24.2K
When the fitness of a trait is influenced by how common it is (i.e., its frequency) relative to different traits within a population, this is referred to as frequency-dependent selection. Frequency-dependent selection may occur between species or within a single species. This type of selection can either be positive—with more common phenotypes having higher fitness—or negative, with rarer phenotypes conferring increased fitness.
24.2K
02:39Predator-Prey Interactions
21.7K
Predators consume prey for energy. Predators that acquire prey and prey that avoid predation both increase their chances of survival and reproduction (i.e., fitness). Routine predator-prey interactions elicit mutual adaptations that improve predator offenses, such as claws, teeth, and speed, as well as prey defenses, including crypsis, aposematism, and mimicry. Thus, predator-prey interactions resemble an evolutionary arms race.
21.7K
02:02Responses to Salt Stress
14.6K
Salt stress—which can be triggered by high salt concentrations in a plant’s environment—can significantly affect plant growth and crop production by influencing photosynthesis and the absorption of water and nutrients.
14.6K
02:24Comparative Excretory Systems
26.7K
Animals have evolved different strategies for excretion, the removal of waste from the body. Most waste must be dissolved in water to be excreted, so an animal’s excretory strategy directly affects its water balance.
26.7K
03:20The Stanford Prison Experiment
24.8K
The famous and controversial Stanford Prison Experiment, conducted by social psychologist Philip Zimbardo and his colleagues at Stanford University, demonstrated the power of social roles, social norms, and scripts.
24.8K