Related Experiment Video
Updated: Aug 7, 2026

Development of Recombinant Proteins to Treat Chronic Pain
Published on: April 11, 2018
Extended-release opioids for the management of chronic non-malignant pain
1University of Kentucky Medical Center, Department of Anesthesiology, 800 Rose Street, Suite N212, Lexington, KY 40536, USA. paulsloan1956@yahoo.com
Abstract:
Recent clinical trials have documented the use of extended-release (ER) opioids in the management of chronic non-malignant pain. This manuscript reviews the clinical pharmacology of investigational and current marketed ER opioids. Recent randomised clinical trials of ER opioids that document the efficacy and safety of opioid therapy for chronic pain are reviewed. Finally, the abuse liability of ER opioids is discussed. Current technologies aimed at defeating the abuse of ER opioids will also be presented.
Related Concept Videos
Opioid Analgesics: Synthetic and Semisynthetic Opioids
Analgesia and Pain Management
Opioid Analgesics: Morphine and Other Natural Cogeners
Opioid Receptors: Overview
Oral Drug Delivery Systems: Continuous-Release Systems
Modified-Release Drug Delivery Systems: Overview
