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Related Experiment Videos

Benign partial epilepsy in infancy: myth or reality?

Joseph Kaleyias1, Divya S Khurana, Ignacio Valencia

  • 1Department of Pediatrics, Division of Neurology, St. Christopher's Hospital for Children, Drexel University College of Medicine, Philadelphia, Pennsylvania 19134-1095, USA.

Epilepsia
|July 11, 2006
PubMed
Summary

Benign partial epilepsy in infancy (BPEI) is a distinct neurological condition characterized by specific seizure patterns and normal development. This study further defines BPEI in infants, confirming its unique status in epilepsy diagnosis.

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Area of Science:

  • Pediatric Neurology
  • Epileptology
  • Infant Neurology

Background:

  • Benign partial epilepsy in infancy (BPEI) was first described in 1987.
  • Characterization of BPEI in a US-based infant cohort is needed.

Purpose of the Study:

  • To further characterize benign partial epilepsy in infancy (BPEI).
  • To describe a series of infants diagnosed with BPEI in the United States.

Main Methods:

  • Retrospective study of patients diagnosed with epilepsy between 2002 and 2004.
  • Inclusion criteria: infants satisfying BPEI criteria.

Main Results:

  • Sixteen infants (10.2%) met BPEI criteria; mean seizure onset at 8 months.
  • Seizures presented as behavioral arrest, apnea, eye deviation, or mild clonic movements.

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  • All infants had normal neurological exams, development, interictal EEGs, and brain MRIs; 94% responded well to treatment.
  • Conclusions:

    • Benign partial epilepsy in infancy (BPEI) is a unique epilepsy syndrome.
    • BPEI should be considered in the differential diagnosis of infantile partial epilepsies.