[Demonstration of the central effects of D,L-kawain with EEG brain mapping]

In a double-blind, placebo-controlled EEG-brain-mapping study Saletu et al. demonstrated the encephalotropic effects of single doses of 200, 400 and 600 mg D,L-kawain in healthy volunteers. The substance induced a dose-dependent increase in delta, theta and alpha 1 power, as well as a decrease in alpha 2 and beta power. The shift towards low frequences indicated a sedative effect of higher doses of D,L-kawain. Changes were most pronounced in the frontal regions. The pharmacodynamic peak was reached in the 1st hour; a 2nd peak was seen in the 8th hour. D,L-kawain at a dose of 200 mg had an initial activating effect, followed at a later stage by a mild sedative effect. Self-rating scales suggested activation after 200 mg, but mild sedation after 600 mg. Psychometric performance improved after all D,L-kawain doses; there were no adverse reactions.