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Updated: Aug 7, 2026

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
Published on: February 13, 2021
Treatment of heart failure in Dutch general practice
Frans J M Bongers1, François G Schellevis, Carel Bakx
1NIVEL (Netherlands Institute of Health Services Research), P,O, Box 1568 3800 BN Utrecht, The Netherlands. F.bongers@nivel.nl
Insights
Heart failure medication prescription rates in general practice are significantly influenced by patient age and co-existing conditions, but not gender. Socioeconomic status has a minor impact on prescribing patterns for these cardiovascular drugs.
Area of Science:
- Cardiology
- General Practice
- Pharmacoepidemiology
Background:
- Investigating cardiovascular drug prescription patterns in heart failure (HF) patients within general practice.
- Examining the influence of sociodemographic factors and comorbidities on HF medication use.
Purpose of the Study:
- To determine the relationship between prescription rates of cardiovascular drugs (ACE-inhibitors/ARBs, beta-blockers, diuretics) and patient characteristics.
- To analyze how age, gender, socioeconomic status, and comorbidities affect medication choices for heart failure patients.
Main Methods:
- Utilized data from the second Dutch National Survey in General Practice (2001).
- Included 96 general practices and 374,000 patients.
- Analyzed electronic medical records for diagnoses and prescriptions, supplemented by a 76% response rate postal questionnaire for sociodemographic data.
Main Results:
- Identified 2771 heart failure patients (7.1 per 1000), with a mean age of 77.7 years; 68% were ≥75 years old, and 55% were female.
- Prescription rates: RAAS-I (50%), beta-blockers (32%), diuretics (86%). Combination therapy prescribed in 18%.
- Prescription variations were primarily associated with patient age and the presence of concomitant diseases.
Conclusions:
- Cardiovascular drug prescription for heart failure is largely driven by patient age and comorbidities.
- Gender showed no significant influence, while socioeconomic status had a minor effect on prescription rates.
Background:
To study the relation between the prescription rates of selected cardiovascular drugs (ACE-inhibitors and Angiotensin receptor blockers, beta-blockers, diuretics, and combinations), sociodemographic factors (age, gender and socioeconomic class) and concomitant diseases (hypertension, coronary heart disease, cerebrovascular accident, heart valve disease, atrial fibrillation, diabetes mellitus and asthma/COPD) among patients with heart failure cared for in general practice.
Methods:
Data from the second Dutch National Survey in General Practice, conducted mainly in 2001. In this study the data of 96 practices with a registered patient population of 374.000 were used. Data included diagnosis made during one year by general practitioners, derived from the electronic medical records, prescriptions for medication and sociodemographic characteristics collected via a postal questionnary (response 76%)
Results:
A diagnosis of HF was found with 2771 patients (7.1 in 1000). Their mean age was 77.7 years, 68% was 75 years or older, 55% of the patients were women. Overall prescription rates for RAAS-I, beta-blockers and diuretics were 50%, 32%, 86%, respectively, whereas a combination of these three drugs was prescribed in 18%. Variations in prescription rates were mainly related to age and concomitant diseases.
Conclusion:
Prescription is not influenced by gender, to a small degree influenced by socioeconomic status and to a large degree by age and concomitant diseases.
Related Concept Videos
Heart Failure V: Medical Management
Heart Failure VI: Adjunct Therapies
Heart Failure VII: Nursing Interventions
Heart Failure Drugs: β-Blockers
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
Heart Failure Drugs: Diuretics
