Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Inheritance in lymphoproliferative disorders].

Viggo Jønsson1, Jørgen H Olsen

  • 1Oslo Universitet, Aker Universitetssygehus, Haematologisk Afdeling, N-0514 Oslo. viggo.jonsson@medisin.uio.no

Ugeskrift for Laeger
|July 11, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Meiotic drive in chronic lymphocytic leukemia compared with other malignant blood disorders.

Scientific reports·2022
Same author

Contemporary N<sub>2</sub> and SF<sub>6</sub> multiple breath washout in infants and toddlers with cystic fibrosis.

Pediatric pulmonology·2022
Same author

Inheritance of Susceptibility to Malignant Blood Disorders.

Scientific reports·2019
Same author

Socioeconomic inequality in cancer survival - changes over time. A population-based study, Denmark, 1987-2013.

Acta oncologica (Stockholm, Sweden)·2019
Same author

Radiation Therapy for Treatment of Adolescent and Young Adult Hodgkin Lymphoma and Risk for Cardiovascular Disease and Cancer.

Journal of adolescent and young adult oncology·2018
Same author

Neurologic disorders in 4858 survivors of central nervous system tumors in childhood-an Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study.

Neuro-oncology·2018
Same journal

[Mosaicism as a cause of Cowden syndrome].

Ugeskrift for laeger·2026
Same journal

[Thyrotoxic crisis with cardiogenic shock].

Ugeskrift for laeger·2026
Same journal

[Mindfulness-based cognitive therapy in the treatment of depression].

Ugeskrift for laeger·2026
Same journal

[Fitness].

Ugeskrift for laeger·2026
Same journal

[Risk of developing cataract related to fluoroscopy].

Ugeskrift for laeger·2026
Same journal

[Obturator hernia with small bowel ileus presenting as hip pain in an elderly woman].

Ugeskrift for laeger·2026
See all related articles

Familial clustering of lymphoproliferative disorders like chronic lymphocytic leukemia (CLL) suggests a hereditary component. Research in Denmark indicates strong parent-child transmission patterns, particularly for CLL, hinting at a non-Mendelian inheritance.

Area of Science:

  • Hematology
  • Genetics
  • Epidemiology

Context:

  • Lymphoproliferative disorders, including chronic lymphocytic leukemia (CLL), non-Hodgkin's lymphoma, Hodgkin's lymphoma, and multiple myeloma, are recognized as having hereditary components.
  • Denmark's high CLL incidence and comprehensive cancer registration since 1943 provide a unique setting for genetic and epidemiological studies.

Purpose:

  • To investigate the genetic basis and inheritance patterns of lymphoproliferative disorders within families.
  • To explore potential familial clustering and transmission of specific lymphoproliferative malignancies.

Summary:

  • Genealogical and epidemiological data from Denmark reveal strong parent-child linkages for lymphoproliferative disorders, especially chronic lymphocytic leukemia (CLL).
  • The study observed a predominant transmission pattern of CLL from parent to child, with similar conservative patterns noted for non-Hodgkin's and Hodgkin's lymphomas.

Related Experiment Videos

  • No significant linkage to other cancer types was detected, and a non-Mendelian mode of inheritance is suggested for familial clustering.

    • Impact:

    • Highlights the hereditary nature of lymphoproliferative disorders and identifies specific transmission patterns.
    • Suggests potential avenues for future genetic research into the etiology of these hematological malignancies.
    • Provides valuable insights for genetic counseling and understanding familial cancer risks.