Related Experiment Video
Updated: Aug 7, 2026

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids
Published on: April 25, 2016
Long-term efficacy of trilostane administered twice daily in dogs with pituitary-dependent hyperadrenocorticism
Dolores Perez Alenza1, Carolina Arenas, Mari Luz Lopez
1Veterinary Teaching Hospital, Veterinary School, Complutense University of Madrid, Madrid, Spain.
Abstract:
Trilostane is considered an efficacious and safe medication for canine pituitary-dependent hyperadrenocorticism (PDH). Its recommended frequency of administration is once daily. In this prospective study, the efficacy, toxicity, and long-term outcome of trilostane administered twice daily per os were evaluated in 44 dogs with PDH. Mean initial dose was 3.1 mg/kg q 12 hours, and mean final dose was 3.2 mg/kg q 12 hours. The final total daily dose was lower than previously reported for once-daily administration. The mean survival time for affected dogs was 930 days.
Related Concept Videos
Cushing Syndrome II: Pathophysiology
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
Cushing Syndrome I: Introduction
Drug Accumulation During Multiple Dosing: Repetitive IV Injections
Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

