Local protein synthesis and spine morphogenesis: Fragile X syndrome and beyond
Aaron W Grossman1, Georgina M Aldridge, Ivan Jeanne Weiler
1Beckman Institute, University of Illinois at Urbana--Champaign, Urbana, Illinois 61801, USA.
Abstract:
Behavioral experiences can modulate neural networks through changes in synaptic morphology and number. In contrast, abnormal morphogenesis of dendritic spines is associated with cognitive impairment, as in Fragile X syndrome. Dendritic or synaptic protein synthesis could provide the specificity and speed necessary for spine morphogenesis. Here, we highlight locally translated proteins shown to affect synaptic morphology (e.g., Fragile X mental retardation protein).
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