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Updated: Aug 7, 2026

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells
Published on: May 18, 2018
The regulatory role of dendritic cells in the immune tolerance
Yin-Ping Li1, Véronique Latger-Canard, Luc Marchal
1Laboratory of Mechanobiology and Engineering of Cells and Tissues, CNRS UMR 7563, Faculty of Medicine and Unit of Cellular and Tissue Therapy, CHU, Nancy, France.
Abstract:
Immune homeostasis is important for the protection of a host from pathogen aggression, as well as for preventing autoimmunity. Dendritic cells (DCs), the most potent antigen presenting cells, are critical in innate, adaptive immunity and in central tolerance. Recently, their involvement in peripheral tolerance has been shown. Whether DCs induce immunity or tolerance depends on their state of maturation. Different subsets of tolerogenic DCs have been identified in vivo, either in physiological, or pathological conditions, such as tumors, or GVHD. Moreover, tolerogenic DCs can be generated in vitro, by using different culture conditions, such as IL-10 or TGF-beta. In our study, we obtained tolerogenic DCs, by culturing them in the presence of human mesenchymal stem cells (MSCs).
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