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Prophylaxis and screening options: recommendations for young women with BRCA mutations
Jonathan C Samuel1, David W Ollila
1Division of Surgical Oncology, University of North Carolina at Chapel Hill, 3010 Old Clinic Building, CB 7213, 27599-7213, USA.
Abstract:
Young women who carry a BRCA mutation face difficult decisions regarding radiologic screening modalities and prophylactic surgery. Decisions regarding these choices may have short and/or long-term consequences and significant impacts on breast cancer risk. A comprehensive review of currently available data supports the following recommendations for young women with BRCA mutations: perform monthly self breast exam, obtain clinical breast exam 2-4 times per year, discuss annual imaging options with a breast specialist, complete child-bearing by 35 with subsequent prophylactic oopherectomy, avoid hormone replacement therapy, and consider prophylactic mastectomy.
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