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Related Experiment Videos

Alterations in plasma complement levels after human ischemic stroke.

J Mocco1, David A Wilson, Ricardo J Komotar

  • 1Department of Neurological Surgery, Columbia University, New York, New York 10032, USA.

Neurosurgery
|July 11, 2006
PubMed
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Complement activation occurs after stroke, with early increases in C3a and delayed rises in C5a. These findings in human ischemic stroke suggest a complex, component-specific response.

Area of Science:

  • Neuroscience
  • Immunology
  • Cardiovascular Medicine

Background:

  • Stroke is a major cause of death and disability.
  • Animal studies suggest complement system inhibition may improve outcomes in cerebral ischemia/reperfusion injury.
  • Human complement activation patterns after stroke require elucidation.

Purpose of the Study:

  • To investigate the characteristics and time course of human complement activation following ischemic stroke.
  • To compare complement factor levels in stroke patients versus matched controls.

Main Methods:

  • Peripheral blood levels of complement factor 3a (C3a), 5a (C5a), and sC5b-9 were measured in 15 stroke patients on multiple days post-stroke.
  • Levels were compared to age-, race/ethnicity-, and sex-matched controls.

Related Experiment Videos

  • Statistical analysis used unpaired Mann-Whitney nonparametric tests with Bonferroni correction.

    • Main Results:

    • C3a levels were significantly elevated early after stroke (Days 1-7) and on Day 28.
    • C5a levels showed significant delayed elevations between poststroke Days 7 and 14.
    • sC5b-9 levels were significantly depressed on poststroke Days 1 and 2.

    Conclusions:

    • Complement component 3a (C3a) is acutely elevated post-stroke.
    • Complement component 5a (C5a) exhibits delayed elevation 7-14 days after ischemic stroke.
    • Soluble C5b-9 (sC5b-9) is acutely depressed post-stroke, indicating heterogeneous complement activation.