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Metabolic cycles as an underlying basis of biological oscillations
Benjamin P Tu1, Steven L McKnight
1Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas 75390, USA. bentu@biochem.swmed.edu
Abstract:
The evolutionary origins of periodic phenomena in biology, such as the circadian cycle, the hibernation cycle and the sleep-wake cycle, remain a mystery. We discuss the concept of temporal compartmentalization of metabolism that takes place during such cycles, and suggest that cyclic changes in a cell's metabolic state might be a fundamental driving force for such biological oscillations.
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