Related Experiment Video
Updated: Aug 7, 2026
Transcanalicular Diode Laser-assisted Dacryocystorhinostomy for the Treatment of Primary Acquired Nasolacrimal Duct Obstruction
Published on: October 13, 2017
Bioactive glass S53P4 in frontal sinus obliteration: a long-term clinical experience
Matti Peltola1, Kalle Aitasalo, Jouko Suonpää
1Department of Otorhinolaryngology, Head and Neck Surgery, Turku University Hospital, FIN-20521 Turku, Finland. matti.peltola@tyks.fi
Background:
Synthetic, osteoconductive, and antimicrobial bioactive glass (BAG) has been used in many surgical applications.
Methods:
BAG was used as obliteration material in a series of osteoplastic frontal sinus operations on 42 patients suffering from chronic frontal sinusitis, which could not be cured with other means of treatment.
Results:
Accurate obliteration of sinuses was achieved in 39 patients. Uneventful recovery and clinical outcome were seen in 92% of the patients. Histopathologic samples harvested at 1, 5, and 10 years after obliteration revealed a healing process progressing from the fibrous tissue phase to bone formation with scattered fibrous tissue and bony obliteration maintaining BAG granule remnants. Fourier-transform infrared (FTIR) studies showed bone produced by BAG to be similar to natural frontal bone. Micorobiologic cultures obtained with histologic samples revealed no growth of bacteria.
Conclusions:
BAG appears to be a reliable frontal sinus obliteration material, providing favorable conditions for total bony sinus obliteration.
