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Determination of Tolerable Fatty Acids and Cholera Toxin Concentrations Using Human Intestinal Epithelial Cells and BALB/c Mouse Macrophages
Published on: May 30, 2013
Transepithelial immunomodulation by cholera toxin and non-toxic derivatives
Fabienne Anjuère1, Carmelo Luci, Catherine Hervouet
1INSERM U 721, Mucosal Immunity and Vaccinology, Faculté de Médecine Pasteur, 06107 Nice, France.
Abstract:
Comparative analyses of murine dendritic cells (DC) isolated from the skin and from the intestinal mucosa after exposure to cholera toxin and its non-toxic B subunit disclose striking differences regarding the migratory and functional behaviour of these cells. The nature of the epithelial microenvironment, especially locally produced cytokines and chemokines, appears to influence the functional ability of skin and mucosal DCs to convey immunogenic as opposed to tolerogenic signals and hence to regulate immune responsiveness at skin and at mucosal sites.
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