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Related Experiment Videos

The interferon-inducible GTPases.

Sascha Martens1, Jonathan Howard

  • 1Division of Neurobiology, MRC Laboratory of Molecular Biology, Cambridge CB2 2QH, United Kingdom. martens@mrc-lmb.cam.ac.uk

Annual Review of Cell and Developmental Biology
|July 11, 2006
PubMed
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Mammalian cells activate many genes in response to interferons (IFNs) during infection. This review explores the roles of poorly understood GTPases in disease resistance and potential shared mechanisms.

Area of Science:

  • Immunology
  • Molecular Biology
  • Cellular Biology

Background:

  • Mammalian cells activate numerous genes upon interferon (IFN) secretion during infection.
  • IFNs prepare cells and organisms for infection resistance through regulated gene products.
  • Many highly induced proteins are GTPases with unclear functions.

Purpose of the Study:

  • To review progress in understanding GTPase family roles in disease resistance.
  • To identify common mechanisms among IFN-induced GTPases.

Main Methods:

  • Literature review of studies on GTPases and interferon responses.
  • Analysis of existing data on gene expression and protein function.

Main Results:

  • Identified various GTPase families induced by interferons.

Related Experiment Videos

  • Highlighted the poorly understood functions of these abundant proteins.
  • Found emerging evidence for common mechanistic roles.

    • Conclusions:

    • GTPases are significantly upregulated by interferons during infection.
    • Further research is needed to elucidate GTPase functions in disease resistance.
    • Understanding these GTPases may reveal novel host defense strategies.