Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Current and future molecular diagnostics for prion diseases.

Marty T Lehto1, Harry E Peery, Neil R Cashman

  • 1Amorfix Life Sciences, 3080 Yonge Street, Suite 6020, Toronto, M4N 3N1, Canada. marty.lehto@amorfix.com

Expert Review of Molecular Diagnostics
|July 11, 2006
PubMed
Summary

Prions, misfolded proteins causing untreatable spongiform encephalopathies like Creutzfeldt-Jakob disease, require novel detection assays. This review covers technologies for identifying these unique protein complexes for better prion disease diagnosis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Could anticholinergics accelerate ALS progression? A critical perspective on drug safety and disease vulnerability.

Expert opinion on drug safety·2026
Same author

Longitudinal Analysis of Superoxide Dismutase 1 Seeding Activity in Amyotrophic Lateral Sclerosis Cerebrospinal Fluid.

medRxiv : the preprint server for health sciences·2026
Same author

Reliable repurposing of the antibody interactome inside the cell.

Nature communications·2026
Same author

Basic Science and Pathogenesis.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Drug Development.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Relationship between efficacy and preferential targeting of soluble Aβ aggregates.

Alzheimer's & dementia (New York, N. Y.)·2025

Area of Science:

  • Neuroscience
  • Protein Biochemistry
  • Infectious Diseases

Background:

  • Transmissible spongiform encephalopathies (TSEs) are fatal neurodegenerative diseases.
  • Prions, misfolded prion proteins, are the infectious agents underlying TSEs.
  • Diseases like Creutzfeldt-Jakob disease (human) and bovine spongiform encephalopathy (cattle) are untreatable.

Purpose of the Study:

  • To review conventional and disruptive technologies for prion detection and diagnosis.
  • To highlight assays that target unique prion protein properties, not nucleic acids.
  • To address the challenge of diagnosing prion diseases, including during presymptomatic incubation.

Main Methods:

  • Review of existing and emerging diagnostic technologies for prion diseases.

Related Experiment Videos

  • Focus on assays exploiting prion-specific biochemical properties.
  • Comparison of different technological approaches for prion detection.

    • Main Results:

    • Various technologies exist for prion detection, ranging from conventional to disruptive.
    • Assays targeting misfolded prion protein complexes show promise.
    • No single method is universally applied, necessitating diverse technological development.

    Conclusions:

    • Developing novel assays is crucial for detecting and diagnosing prion diseases.
    • Exploiting prion protein characteristics is key for effective diagnostics.
    • Advancements in technology are essential for managing and potentially treating prion disorders.