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In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
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Published on: January 20, 2019

Understanding and making use of human memory B cells

Antonio Lanzavecchia1, Nadia Bernasconi, Elisabetta Traggiai

  • 1Institute for Research in Biomedicine, Bellinzona, Switzerland. lanzavecchia@irb.unisi.ch

Immunological Reviews
|July 11, 2006
PubMed

The work of our laboratory has focused on the study of human memory B cells. Using an in vitro approach we dissected the triggering requirements of B cells and unveiled a distinct role for TLRs in the activation of naive versus memory B cells. Using an ex vivo approach we analyzed the dynamics of memory B cells and ASCs and the kinetics of serum antibodies during secondary immune responses and in steady state conditions and used these quantitative data to build up a model of serological memory. According to this model memory B cells behave as ;stem cells' capable of generating plasma cells and antibodies in an antigen-dependent as well as in an antigen-independent fashion. Finally we developed an efficient method to interrogate human memory B cells and to isolate human monoclonal antibodies. This method can be exploited for the production of neutralizing antibodies for serotherapy and for "analytic vaccinology".

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